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When administered, the hormone regulates blood sugar levels and does the following: Stimulates the release of insulin from pancreatic beta cells as a response to elevated blood sugar levels Reduces the release of a hormone glucagon that increases blood sugar levels Slows down the rate at which food moves through the stomach, which increases feelings of fullness and reduces appetite Semaglutide and Weight Loss Studies support the effectiveness of Semaglutide in causing significant weight loss when used as a treatment for obesity