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The evidence for cardiovascular benefits of GLP-1 RA and SGLT2i in those with only risk factors for CVD, based on MACE (myocardial infarction, stroke or cardiovascular death), is less robust, as fewer people with lower event rates are included in studies [313,314,315]
Semaglutide: Average increase of 23 bpm in trials, with a subset reaching 10 bpm or more
Presented for research literature review only Deponte M (2013)
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