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Diabetologia 55 (12), 32623272
The accumulation of HNE is thought to have a significant impact on the disruption of metabolic pathways, leading to abnormalities in glucose metabolism, neuronal trafficking, and antioxidant responses (Barone et al
But tirzepatide can lower how much of the pill gets absorbed, so backup contraception is advised for 4 weeks after starting or increasing the dose (7)
The downstream effect of this slowing is that GLP-1s reduce the speed at which food passes through the body, thereby delaying its conversion into waste
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