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Conditions that affect the gut, like Crohns disease or celiac disease, can damage the intestinal lining, making it difficult for B12 to pass into your bloodstream
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Experimental evidence from knockout models suggests that reduced NNMT activity is associated with resistance to tumor formation, leading to speculation about a possible role for this enzyme in cancer biology
The research rationale for a selective NNMT inhibitor is to interrupt exactly that diversion, so the cell keeps more of its NAD+ pool and can run its mitochondrial machinery again
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