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Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis
Taking this into account, the strong anti-inflammatory activity exhibited in the study was assigned to two multifunctional peptides from the hydrolysate: FAGPPGGDGQPGAK (FK-14) and IAGPAGPRGPSGPA (IA-14), which owing to the high content of hydrophobic and positively charged amino acids at the N and C termini of the peptide chain, promoted this anti-inflammatory effect (Reference Liu, Yang and Liu120)
ET-1 antagonism: bosentan Bosentan, an ET-1 receptor antagonist, has been applied in the treatment of HAPH
While the G-site is more hydrophilic in nature compared to the H-site, the extent of hydrophobicity of the H-site varies across GST classes and amongst individual GSTs [77, 78, 91]
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