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5 Immune system irregularities (eg, autoimmunity, chronic inflammation), undetected chronic infection, inflammation and/or hyperexcitability of the bladder nerves, and altered signaling between the bladder and other pelvic tissues may also contribute

Meanwhile, ROCK can enhance the transduction of transforming growth factor-1/suppressor of mothers against decapentaplegic homolog signaling [40], thereby inducing endothelial-to-mesenchymal transition, increasing fibrosis markers, and structural remodeling of the microvasculature in the CC [41]

A dose that supports one organ system may be excessive for another

The respiratory control ratio (RCR), a key measure of coupling efficiency (V3/V4), was significantly increased by DSIP at 10 and 10 M concentrations, suggesting tighter coupling between respiration and phosphorylation