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Description

The foundational GHK-Cu work found collagen stimulation in human fibroblasts beginning around 1010 M and peaking near 10 M the same potency window later reported for AHK-Cu [10]

Clinical features such as fatigue, paraesthesia, glossitis, and cognitive changes support the diagnosis

The strongest evidence is preclinical but directly tests NNMT inhibition in metabolic disease models

Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action 5-Amino-1MQ works by blocking the NNMT enzyme , which is responsible for consuming nicotinamide and depleting NAD+ stores