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The cardiovascular benefits appear to precede any significant weight management and apply to people with or without type 2 diabetes
GLP-1 medicines have changed what is possible in obesity and type 2 diabetes, but they require chronic, high-dose systemic exposure that many patients cannot or do not sustain, said Harith Rajagopalan, MD, PhD, co-founder and CEO of Fractyl Health
/ Ensure your blood pressure and heart rate are in a normal range
But neuropeptide receptors can downregulate under chronic stimulation
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