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The highly documented later development of migraine (up to 75% of children) suggests a progressive continuum from CVS to migraine headaches in most children (13, 27, 2931)
Furthermore, 4-hydroxyproline inhibits the production of hydroxyl radical via the Fenton reaction possibly through: (a) formation of coordinate bonds with iron, (b) sequestration of Fe 2+ , and (c) interactions with intermediates of the reaction via hydrophobic hydration (Mili et al
syringae effector HopAI1, alleviates LET7 autoinhibition and promotes the HOP1LET7 interaction, ultimately elevating LET7 phosphatase activity to trigger autoimmunity
