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Clinical trials using oxandrolone for muscle wasting (Grunfeld et al., 2006, JCEM) showed real lean mass and strength improvements, meaning the compound is not physiologically inert even if gains are modest
No human clinical trials of Dihexa itself published as of 2026
Additional research has explored MSM's role in supporting cartilage health through its sulfur content
Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis
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