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Currently, there are clinical studies using AAV vectors to transfect sarcoplasmic/endoplasmic reticulum Ca (2+)-ATPase (SERCA2a) to treat heart failure [255, 256]
Regular routine skincare and natural intake of vitamins C and E enhance the efficacy of the treatment for a longer period of time
Previous studies have shown that a small molecule called Ras Lethal 3 ((1S,3R)-RSL3,(RSL3)) can pharmacologically inhibit GPX4 in skin and soft tissue cancer models in vitro and leads to induction of ferroptosis 10,11
ERAD helps mitigate this burden by degrading these proteins, thereby preventing their aggregation and the subsequent activation of detrimental pathways, such as chronic ER stress, autophagy dysfunction, and apoptotic signaling
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