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Glucagon acts in the liver via cAMP (Abbas et al., 2020), and glucagon is secreted by cells as an immediate response to glucose reduction

The effect is a reduced appetite and cravings

GLP-1s may additionally impact other physiological changes observed in the perimenopausal period, including vasomotor symptoms like hot flashes and night sweats, declines in bone health, and unhealthy changes in body composition (gains in fat mass and declines in muscle mass), but whether these impacts are beneficial or harmful for women's health remains unknown

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