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In this review, the mechanism of action of GLP-1 receptor agonists on glucose metabolism and on the kidney are discussed as well as the (pre)clinical data that currently are suggestive of renoprotection, and potentially involved pathways
Glucagon also contributes to energy homeostasis by promoting satiety through vagal signaling to brainstem nuclei and by increasing resting energy expenditure through facultative thermogenesis in brown adipose tissue, skeletal muscle, and through promotion of WAT browning [22]
NNC0090-2746 (RG7697) is a compound that has been tested in multiple preclinical and clinical studies as a dual GIPR/GLP-1R agonist [58,59,60]
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