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JAMA (2020) 323(6):54860
Unlike receptor-defined peptide systems such as GLP-1 receptor agonists, amylin analogs, or growth-hormone / GHRH-related receptor-targeted peptides, BPC-157s reported effects have been attributed in published research to modulation of several intersecting signaling pathways without a definitively established primary molecular target
Kleinman WA, Richie JP Jr
Serious but less common adverse effects include pancreatitis, gallbladder disease, acute kidney injury (particularly in the setting of dehydration from gastrointestinal symptoms), and hypoglycemia when used in combination with insulin or sulfonylureas
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