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In preclinical research, blocking NNMT raised NAD+ inside fat cells, increased their metabolic activity, and reduced fat-cell size notably without changes to diet
Research using functional magnetic resonance imaging (fMRI) has shown that GLP-1 directly influences key brain regions involved in appetite regulation
The sc infusion was necessary because the GLP-1 molecule is cleared extremely rapidly in the body (intravenous (IV) half-life of 1-2 min.) due to the actions of an enzyme, dipeptidyl peptidase 4 (DPP-4), which inactivates the peptide [13]
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