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They named it a triple agonist because it targets GLP-1, GIP, and glucagon receptors
Most peptides are cleaved by proteases in the stomach and small intestine before meaningful absorption occurs
GLP-1s like Wegovy and Mounjaro have four mechanisms to improve blood sugar levels and support weight loss: Improve insulin function: Improving insulin response to glucose from meals enables the body to move glucose from the blood and into the cells (like muscle cells) to be burnt for energy or stored as glycogen
Therefore, by transfecting M cell lines with targeted Apollo-NADP + sensors and treating cells with 2-DG and diamide, we can measure NADPH consumption by GSR in the cytosol or mitochondria in a kinetic assay
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