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Other testicular cells called Leydig cells produce testosterone when stimulated by another pituitary hormone known as luteinizing hormone (LH)
GRB2 depletion leads to fork collapse, cytosolic DNA accumulation, cGASSTING activation, and increased PARPi sensitivity
As with many other neuropeptides, individual response can vary
Its levels gradually decline with age, correlating with increased mitochondrial oxidative damage
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