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It works by mimicking GLP-1, a natural hormone that regulates appetite, slows digestion, and stabilizes blood sugar
Published online September 25, 2021
In brief, HCT116 cells were infected with the GeCKO v1 human CRISPR knockout pooled library using lentiviral transduction at a multiplicity of infection of 0.3, and populations stably expressing gRNAs were selected for using puromycin and expanded for 8 days to allow for essential gene drop-out
Administration of GLP-1 or GLP-1RAs (including exenatide, geniposide, liraglutide, lixisenatide, and semaglutide) enhances neurogenesis in the dentate gyrus, hippocampus, olfactory bulb, and medial striatum in animal models, while modulating apoptotic pathways and increasing animal survival under extreme factors [24]
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