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All animal procedures were conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the ethics committee for experimental animal use at The Affiliated Hospital of Guizhou Medical University (No.2200545)

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377 The TAMRAD phase 2 clinical trial enrolled postmenopausal patients with HR+ metastatic breast cancer who had failed aromatase inhibitor therapy, comparing tamoxifen combined with the mTOR inhibitor everolimus versus tamoxifen monotherapy