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Methods An observational real-world data study assessed patient characteristics and drug utilization in separate SGLT2i and GLP-1 RA new-user cohorts of adults with CKD and type 2 diabetes in an earlier (1 January 201230 June 2021) and a later (9 July 202130 September 2023) period using Optums de-identified Clinformatics Data Mart Database (Optum CDM)

Besides its popularity for weight loss, berberine is also being studied for its effect on diabetes and heart disease risk factors

No adverse effects were documented

Timing Strategies : Distribute fluid intake throughout the day rather than consuming large volumes at once, which may exacerbate nausea or gastric discomfort