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The FDA label states that tirzepatide "may impact the efficacy of oral hormonal contraceptives" and recommends patients switch to a non-oral contraceptive method or add a barrier method for 4 weeks after initiation and 4 weeks after each dose escalation [3]

Katrin Svensson, PhD, an associate professor of pathology at Stanford University who directs a lab doing preclinical peptide research, goes further