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While not everyone experiences this side effect, a significant number of patients report a period of lethargy as their system recalibrates to a new metabolic set point. The relationship between GLP-1 GIP receptor agonists and energy levels Tirzepatide is a dual agonist, meaning it mimics two different hormones in the body: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

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