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In people with both type 2 diabetes and obesity, an indirect comparison drawing on the separate SURMOUNT-2 (NCT04657003) and STEP 2 (NCT03552757) trials, rather than a single head-to-head study, reported weight reduction of up to 15.7% with tirzepatide and 10.6% with semaglutide 2.4 mg
However, their pharmacological effects alter eating behaviour, gastrointestinal dynamics and weight loss patterns in ways that may indirectly influence nutritional status
This alteration in digestion can aid with long-term weight management
However, some patients tolerate one significantly better than the other
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