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Beyond absolute reductions in body weight, improvements in insulin sensitivity appear to be a key mechanistic link between metabolic interventions and attenuation of systemic inflammation
The safety profile of pediatric patients treated with empagliflozin was similar to that observed in adults with type 2 diabetes mellitus, with the exception of hypoglycemia risk which was higher in pediatric patients treated with empagliflozin regardless of concomitant insulin use [see Warnings and Precautions (5.5) and Adverse Reactions (6.1)]
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