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Chaudhary A, Maurya PK, Yadav BS et al (2018) Current therapeutic targets for Alzheimers disease

Some trial participants showed total body weight reductions in the 20-25% range, though these figures come from smaller, shorter studies and should be interpreted with caution until phase 3 data is published

Older adults face steeper deficits because aging reduces the enzymes responsible for natural glutathione production

Overall, these findings demonstrate that this substrate profiling system can both predict and validate physiologically relevant off-target cleavage events, thereby providing critical information for refining protease specificity for intended applications