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Gallbladder disease: GLP-1s (and rapid weight loss) are both linked with increased gallstone risk

[5] [6] In the UK, tirzepatide for weight management is available only through specialist weight management services, with specific eligibility criteria including BMI thresholds (with lower thresholds for some ethnic groups) and weight-related comorbidities

There are also settings beyond pharmacy regulators reach where practices may legitimately raise concern

Additionally, there is an increased risk of gallbladder problems such as gallstones when taking GLP-1 receptor agonists, especially during periods of rapid weight loss