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This alteration in the balance of the extracellular matrix plays a role in the progression of OA ( Figure 4 )
Some scientists believe that low carnitine levels can contribute to this fatigue
If the protease inhibitor PS-341 is used, it protects Nrf2 from being ubiquitinated, thus decreasing the levels of GCLC and GSS
Following the invasion of surrounding tissues cancer cells can extravasate to the distant tissue parenchymas through the vascular system and form small nodules named micrometastases and further macroscopic tumors by colonization that secondary tissue (Hanahan and Weinberg 2011)
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