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majority of TBI and stroke studies Mice Used for transgenic Alzheimers models (APP, APP/PS1) and excitotoxicity studies Humans Multiple clinical trials in stroke, dementia, and TBI populations Cell culture Cortical neurons, hippocampal cultures, endothelial cells for mechanistic studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 1,000 preclinical studies and numerous clinical trials, Cerebrolysin faces substantial translational challenges that significantly limit its therapeutic utility
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GLP-1 and GIP both participate in incretin biology, while glucagon receptor activation may influence energy expenditure, fat oxidation, and liver metabolism
10.1038/cddis.2014.221 56 ZhangQ.LiuJ.DengM
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