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We also see cases where overenthusiastic dosing, opaque compounding, or lack of lifestyle support created avoidable complications

Judge Robert Kirsch wrote that "clinical trials are complicated and nuanced, and investor calls are not scientific conferences." Get the market news that matters in a five-minute read with Market Briefs, our free daily newsletter Investors argue that Novo Nordisk's earlier communications glossed over this design feature, creating an expectation that nearly all participants would reach the highest dose and thus achieve maximum weight loss

If hunger, waist, or weight drift shows up in the back half of the interval, weekly dosing is the cleaner maintenance schedule

This weight gain is theorized to be potentially linked to an increase in adipose tissue relative to the overall body mass