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( d ) Glucose curves and ( e ) corresponding AUCs (6h-0h) for vehicle or D-Ala 2 -GIP administration at 10 and 40 nmol/kg in lean male mice (n = 8 / genotype, age: 18-26 weeks)
& Kara, I
Finally, combining genetic and epigenetic scores has shown greater predictive power for sarcopenia risk compared with genetic variants alone, reinforcing the role of epigenetics as a mediator between genetic predisposition and environmental exposures ( Together, these findings suggest that classical biological and molecular factors of sarcopenia should be reinterpreted through an epigenetic lens, positioning epigenetic regulation as a central link between genetics, environment, and muscle aging (Figure 1)
2023 Mar 18;80(4):100
