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Providers should watch symptoms, flag adverse events, document progress, and decide if therapy continues or stops

Sections of 4 m thickness are prepared using a paraffin microtome (HS3315, Huadu Technology, Zhejiang) and then dried in an oven (GZX-9030MBE, Boxun, Shanghai) at 60C for 1 h

Our 2025 study in JMIR Formative Research examined 12-month outcomes for participants using semaglutide with behavioural support and found 1 : 19.1% average weight loss at 12 months for active subscribers 77.7% achieved at least 10% weight loss 61.5% achieved at least 15% weight loss 69% reported no side effects by month 12 These are completer results (people who stayed on the programme for 12 months), not intent-to-treat

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