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Existing addiction treatments face a number of obstacles to adoption that have severely limited their use, including patient resistance, stigma, side effects, low long-term adherence rates, and, for treatments like methadone, massive cultural resistance that has persisted for over 50 years, despite a mountain of evidence showing the public health benefits of expanded access
A 2025 review found tirzepatide at 15 mg weekly produced weight loss of up to 17.8% over 72 weeks (PubMed)
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