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Poor sleep increases hunger hormones, while chronic stress can amplify cravings
Studies have shown that subjects fed a diet rich in fermentable fibers exhibited a significantly altered ratio of gut bacteria, increased circulating SCFAs in their blood, and were protected against allergic inflammation due to reduced mast cell activation
Orforglipron (Eli Lilly) is a small molecule oral GLP-1 agonist
Additionally, the researchers found that GEP44 exhibits biased agonism at the Y2-R, as documented by its inability to induce Y2-R-mediated increases in intracellular Ca2+ or ERK1/2 phosphorylation
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