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Novo Nordisk appealed and were challenged with demonstrating why the choice of semaglutide, at the particular dose and pH specified in the claim would have not been obvious to the skilled person
1 Introduction Obstructive sleep apnea syndrome (OSAS) is a chronic sleep-related breathing disorder characterized by recurrent upper airway collapse during sleep, leading to intermittent hypoxemia, sleep architecture disruption, and impaired daytime functioning (1, 2)
However, using an ECD-binding antibody Fab fragment (Fab7F38) for co-crystallization, we successfully crystallized the GLP-1RPF-06372222Fab7F38 complex
doi: 10.1136/jim-2021-001952
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