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Lipohypertrophy is described as abnormal fat accumulation at repeatedly used injection sites, which can reduce medication absorption and create visible lumps

Wang T, Gou Z, Wang F, Ma M, Zhai SD

Among patients taking semaglutide: 85% lost at least 10% of their body weight, compared with 7% in the placebo group 62% lost at least 15% of their body weight, compared with 7% in the placebo group 47% lost at least 20% of their body weight, compared with 3% in the placebo group Researchers found that most of the weight loss came from body fat rather than muscle