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Inflammation Res (2016) 65(2):10314
Raw data from the scRNA-seq analyses have been uploaded to the Sequence Read Archive (SRA) of NCBI (Accession: PRJNA118693)
Mechanistically, obesity-induced oxidative stress causes macromolecular damage through ROS-mediated attacks on contractile proteins and DNA, while suppressing antioxidant defenses (e.g., SOD, GPx), impairing satellite cell regenerative capacity and accelerating muscle atrophy 30
One way antioxidants like glutathione help maintain good physical health is by neutralizing free radicals, which can cause cellular damage through oxidation
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