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Cognition and memory also decline with age, and they have been correlated to low IGF-I levels as well[346349], through a proposed mechanism that may include its role in angiogenesis and neurogenesis in the hippocampus
Erythrocyte NAD(H) levels started to saturate already with 500-750 mg of niacin and increasing the dose up to 1000 mg had only a slight additional effect on steady-state NAD + in blood cells
10.1038/s41418-017-0012-4 62 GalluzziL.VitaleI.AbramsJ
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