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127 Similarly, the lactylation of K286 on Tufm, a critical factor in mitophagy, impedes the interaction between Tufm and Tomm40 on mitochondria, thereby suppressing mitophagy and exacerbating mitochondrial dysfunction

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The Fire That Never Goes Out (Chronic Neuroinflammation) Microglia, the brain's immune cells, shift to a pro-inflammatory M1 phenotype to clear debris