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The peptide appears to be permeable into cells, and researchers have suggested selectively inducing senescent cell apoptosis based on results found in studies
You may also be at risk if you take certain medications, such as proton pump inhibitors (Nexium, Prilosec, Prevacid), histamine-2 receptor agonists (Pepcid and Zantac), and metformin for type 2 diabetes
Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]