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IGF-1 levels rise downstream, and visceral adipose tissue decreases in studies ranging from short-term rodent protocols to 52-week human trials
Optimise Your Diet Prioritize whole foods rich in natural folate, B vitamins, and methylation cofactors: Folate-rich foods: Leafy greens (spinach, kale, romaine), asparagus, broccoli, Brussels sprouts, avocado, legumes (lentils, chickpeas, black beans) Choline sources: Eggs, salmon, liver, beef, chicken, cauliflower B12-rich foods: Meat, fish, shellfish, eggs, dairy products B6 sources: Poultry, fish, potatoes, chickpeas, bananas Magnesium: Pumpkin seeds, almonds, spinach, dark chocolate, avocado Critically important: Avoid synthetic folic acid found in fortified foods and standard multivitamins
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For glycemic control, the mean reduction in HbA1c across most T2DM subgroups approaches or reaches the commonly referenced threshold for clinical relevance of 0.5% 47 , and in key target populations (e.g., T2DM with obesity) can reach 0.81.0%, indicating clinically perceptible improvements
