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Increase monitoring rather than pre-emptively reducing dose
Semaglutide in SELECT dropped systolic blood pressure by 3.3 mm Hg, shrunk waist circumference by 6.5 cm, and cut high-sensitivity CRP, a marker of low-grade inflammation, by almost 38%. That last figure is in the same neighbourhood as what statins achieve. Triglycerides came down
These health problems can change the amount of medicine they get and how well the drug works
Its evolutionary significance likely stems from protective functions, particularly in toxin avoidancea mechanism that persists in modern humans and may extend to pregnancy-related protective adaptations
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