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This upregulation is mediated by the binding of hepatic nuclear factor 4 alpha (Hnf4) to the SELENOP promoter, linking dietary composition to hepatic SELENOP regulation and systemic metabolic health [226]
discontinue use if adverse effects occur
M.KurianS
9,12,17 Remaining questions include the longer-term efficacy and safety of these agents, as well as their efficacy and safety in additional populations, including geriatric patients, pediatric patients, or overweight but non-obese adults without comorbidities
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