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Any fraction that does reach the portal circulation then faces first-pass metabolism in the liver
Key effects include: Stimulation of collagen I, III, and V synthesis Increased elastin production Enhanced glycosaminoglycan (GAG) synthesis Promotion of blood vessel growth (angiogenesis) Anti-inflammatory gene modulation Superoxide dismutase upregulation (antioxidant protection) Hair follicle enlargement and growth stimulation How Semaglutide in This Context Semaglutide is a GLP-1 receptor agonist that produces weight loss primarily through appetite suppression and improved metabolic function
Gastrointestinal conditions may show earlier improvement, often becoming apparent during the first month of treatment
As more patients are started on GLP-1 analogues, optometrists should be aware of the frequency of potential worsening retinopathy that occurs with rapid, improved glycemic control
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