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These data indicate that GSH depletion is directly responsible for the observed induction of NRF2 activity in Gclc L-KO mice
( G ) LDH release into coronary effluents from perfused WT mouse hearts, measured by ELISA at timed intervals between 10 and 40 minutes of reperfusion and normalized to coronary flow (mL/min/g heart weight) ( n = 3)
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