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This decline is a direct result of the entrance of more effective agents including Wegovy (semaglutide), approved in 2021, and Zepbound (tirzepatide), approved in 2023

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Our full GH axis research toolkit now comprises three distinct mechanistic entry points: ghrelin receptor agonism (ipamorelin), GHRH receptor agonism (CJC-1295 No DAC, tesamorelin), and direct GH replacement (rhGH) providing researchers with the tools to study GH biology from upstream secretagogue stimulation through to receptor-level replacement

Pro-inflammatory cytokines such as IL-1, IL-6, IFN-, TNF- and pro-inflammatory transcription factors: NF-B (202), AP-1 (203), NFAT (204), STAT1 (205), and HIF-1 (206) induce the expression of iNOS and NO production (202)