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avoid diuretics | | Oral bisphosphonates (alendronate) | Gastric emptying delay may reduce already-low bioavailability | Efficacy loss possible | Minor | Take bisphosphonate on empty stomach 30 min before triple agonist | Prescribing Framework for Triple Agonists No FDA-approved labeling for retatrutide existed as of July 2025, but phase 2 and phase 3 trial protocols establish a de facto dosing framework that clinicians in early-access or clinical-trial settings follow

Roast a large tray of mixed vegetables

Low-Fiber Diet A diet low in fiber can contribute to constipation, making stools harder and more difficult to pass

There is also a concern about the risk of pancreatitis and changes in thyroid function, necessitating monitoring and caution in patients with a history of thyroid disease