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Baseline kidney function testing before initiating either substance, with periodic monitoring based on individual risk factors, represents prudent clinical practice, particularly in patients with diabetes or other kidney disease risk factors

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Meanwhile, orforgliprons oral GLP-1 format may finally unlock mass adoption by removing injection-related barriers, while Survodutide, CT-388, and Pemvidutide demonstrate that dual and triple agonists, with novel combinations of GLP-1, glucagon, and GIP, can outperform monotherapies in both efficacy and metabolic breadth

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