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This effect can enhance endurance, making it an ideal addition to pre-workout supplements and energy-boosting formulas

The most common are gastrointestinal issues, including nausea, which typically occurs during dose escalation, vomiting in some patients, diarrhea or constipation, and abdominal discomfort

In a pilot trial evaluating 104 amnestic MCI and early-stage AD patients, 20 IU and 40 IU doses of intranasal insulin improved Alzheimers Disease Assessment Scale-Cognitive subscale (ADAS-Cog 12) scores compared to placebo-treated patients, with improvements in delayed recall observed 2 months following cessation of treatment in the 20 IU group

and more recently, metabolic-dysfunction associated steatohepatitis (MASH)