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The stimulation of CYP19A1 secretion via FSH requires the activity of IGF-1 receptor (IGF-1R) in humans and rodents [6, 7]
The trial involved 338 adults, with close to a 50/50 split of men and women
The threshold appears lower during the ovulatory and luteal phase (when estradiol levels are high) and higher during menstruation and early follicular phase (when estradiol levels are low) (44, 47, 52)
Zhang T, Tong X, Zhang S, et al
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