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Our aim is to develop a systems approach to understanding GSH metabolism and use this to explain the causes of GSH differences in males and females, how GSH changes during the menstrual cycle, and why women may be less susceptible to acetaminophen toxicity
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While these findings dont directly translate to humans, they raise legitimate concerns about reproductive health, endocrine disruption, and metabolic stress with prolonged, high-dose usage
PMC 11830136
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